2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Xanthine Oxidase

Xanthine Oxidase

XO

Xanthine Oxidase

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Xanthine oxidase (XO), a versatile molybdoflavoprotein, catalyzes the oxidative hydroxylation of purine substrates (hypoxanthine and xanthine) to produce uric acid and subsequent reduction of oxygen at the flavin center with the generation of reactive oxygen species, either superoxide anion radical or hydrogen peroxide.

Xanthine oxidase is an important enzyme of purine catabolism pathway and has been associated directly in pathogenesis of gout and indirectly in many pathological conditions like cancer, diabetes and metabolic syndrome. The selective inhibition of xanthine oxidase may result in a broad spectrum therapeutic use for gout, cancer, inflammation and oxidative damage.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-N10108
    Protosappanin A dimethyl acetal
    		Inhibitor
    Protosappanin A dimethyl acetal is a homoisoflavonoid. Protosappanin A dimethyl acetal can be isolated from Caesalpinia sappan. Protosappanin A dimethyl acetal is also a competive inhibitor with significant xanthine oxidase inhibitory activity (IC50=50.7 μM).
    Protosappanin A dimethyl acetal
  • HY-113978R
    6-Formylpterin (Standard)
    		Inhibitor
    6-Formylpterin (Standard) is the analytical standard of 6-Formylpterin. This product is intended for research and analytical applications. 6-Formylpterin is an inhibitor of Xanthine Oxidase. 6-Formylpterin induces intracellular ROS generation and apoptosis in HL-60 cells. 6-Formylpterin suppresses cell proliferation in PanC-1 cells.
    6-Formylpterin (Standard)
  • HY-161514
    Xanthine oxidase-IN-15
    		Inhibitor
    Xanthine oxidase-IN-15 (Compound 6c) is a selective inhibitor of Xanthine oxidase (XO) (IC50=0.13 μM). Xanthine oxidase-IN-15 inhibits XO catalysis by forming a stable interaction with the active site of XO. Xanthine oxidase-IN-15 is mainly used in the study of hyperuricemia and gout.
    Xanthine oxidase-IN-15
  • HY-12136R
    Purpurogallin (Standard)
    		Inhibitor
    Purpurogallin (Standard) is the analytical standard of Purpurogallin. This product is intended for research and analytical applications. Purpurogallin is a naturally phenol extracted from the plants of Quercus spp, has potent xanthine oxidase (XO) inhibitory activity with an IC50 of 0.2 μM. Purpurogallin has antioxidant and anti-inflammatory effects.
    Purpurogallin (Standard)
  • HY-N0823R
    Lithospermic acid (Standard)
    		Inhibitor
    Lithospermic acid (Standard) is the analytical standard of Lithospermic acid. This product is intended for research and analytical applications. Lithospermic acid ((+)-Lithospermic acid) is a plant-derived polycyclic phenolic carboxylic acid isolated from Salvia miltiorrhiza, and has the anti-oxidative and hepatoprotective activity on carbon tetrachloride (CCl4)-induced acute liver damage in vitro and in vivo.
    Lithospermic acid (Standard)
  • HY-180271
    Xanthine oxidase-IN-21
    		Inhibitor
    Xanthine oxidase-IN-21, a Genipin (HY-17389) derivative, is an orally active mixed competitive xanthine oxidase (XOD) inhibitor with an IC50 of 0.68 μM. Xanthine oxidase-IN-21 reduces renal fibrosis by decreasing α-SMA expression and suppresses pro-inflammatory cytokines IL-1β, IL-6, and TNF-α through NF-κB pathway regulation. Xanthine oxidase-IN-21 also inhibits URAT1 and GLUT9 expression, promoting uric acid excretion and lowering serum uric acid levels. Xanthine oxidase-IN-21 shows significantly hepatorenal protection activity. Xanthine oxidase-IN-21 can be used for the research of hyperuricemia.
    Xanthine oxidase-IN-21
  • HY-14268S2
    Febuxostat-d3
    		Inhibitor
    Febuxostat-d3 (TEI 6720-d3) is deuterium labeled Febuxostat. Febuxostat (TEI 6720) is a potent, selective and non-purine xanthine oxidase (XO) inhibitor with a Ki value of 0.6 nM. Febuxostat has the potential for the research of hyperuricemia and gout.
    Febuxostat-d<sub>3</sub>
  • HY-123383
    Renierol
    		Inhibitor
    Renierol is an orally active xanthine oxidase (XO) inhibitor. Renierol has urate-lowering activity.
    Renierol
  • HY-N4136R
    Lonicerin (Standard)
    		Inhibitor
    Lonicerin (Standard) (Veronicastroside (Standard)) is the analytical standard of Lonicerin (HY-N4136). This product is intended for research and analytical applications. Lonicerin is a flavonoid with multiple biological activities. Lonicerin inhibits xanthine oxidase with an IC50 of 37.4 µg/mL. Lonicerin inhibits alginate secretion protein (AlgE). Lonicerin inhibits P. aeruginosa and C. albicans. Lonicerin has anti-inflammatory, anti-arthritic, antioxidant, antifungal, anti-bacterial, and neuroprotective properties.
    Lonicerin (Standard)
  • HY-N14414
    5-Hydroxy-3,4,7-triphenyl-2,6-benzofurandione
    		Inhibitor
    5-Hydroxy-3,4,7-triphenyl-2,6-benzofurandione is a xanthine oxidase (XO) inhibitor found in Peniophora sanguinea.
    5-Hydroxy-3,4,7-triphenyl-2,6-benzofurandione
  • HY-N1547R
    Prudomestin (Standard)
    		Inhibitor
    Prudomestin (Standard) is the analytical standard of Prudomestin. This product is intended for research and analytical applications. Prudomestin, isolated from the heartwood of Prunus domestica, shows potent xanthine oxidase (XO) inhibitory activity (IC50≈6?μM).
    Prudomestin (Standard)
  • HY-N17699
    Neosakuranin
    		Inhibitor
    Neosakuranin is a flavonoid. Neosakuranin can be isolated from Sorbus commixta and the bark of P. cerasus. Neosakuranin exhibits suppressive effects on xanthine oxidase with an IC50 of 157.8 μM. Neosakuranin inhibits COX-l. Neosakuranin can be used in the research of inflammatory diseases.
    Neosakuranin
  • HY-W015069
    4-Nitrocinnamic acid
    		Inhibitor 99.88%
    4-Nitrocinnamic acid is a Phenylpropanoids product that can be isolated from the heartwoods of Cassia garrettiana.
    4-Nitrocinnamic acid
  • HY-W010132
    5-Nitrobenzimidazole
    		Inhibitor 99.74%
    5-nitrobenzimidazole is a genotoxic nitro compound and 6-aminopurine (HY-B0152) analogue. 5-nitrobenzimidazole shows a slight inhibitory effect on xanthine oxidase, with an IC50 of 86.84 μM. 5-nitrobenzimidazole can be used in the research of hyperuricemia.
    5-Nitrobenzimidazole
  • HY-14874R
    Topiroxostat (Standard)
    		Inhibitor
    Topiroxostat (Standard) is the analytical standard of Topiroxostat. This product is intended for research and analytical applications. Topiroxostat (FYX-051) is a potent and orally active xanthine oxidoreductase (XOR) inhibitor with an IC50 value of 5.3 nM and a Ki value of 5.7 nM. Topiroxostat exhibits weak CYP3A4-inhibitory activity (18.6%). Topiroxostat has the potential for hyperuricemia treatment.
    Topiroxostat (Standard)
  • HY-19164
    BOF-4272
    		Inhibitor
    BOF-4272 is a xanthine oxidase/xanthine dehydrogenase inhibitor. BOF-4272 can be used for hyperuricemia research.
    BOF-4272
  • HY-19657R
    Oxypurinol (Standard)
    		Inhibitor
    Oxypurinol (Standard) is the analytical standard of Oxypurinol. This product is intended for research and analytical applications. Oxipurinol (Oxipurinol), the major active metabolite of Allopurinol, is an inhibitor of xanthine oxidase. Oxipurinol can be used to regulate blood urate levels and treat gout.
    Oxypurinol (Standard)
  • HY-N14777
    Hydroxyakalone
    		Inhibitor
    Hydroxyakalone is an inhibitor of Xanthosine oxidase (XOD, EC 1.2.3.2), with an IC50 of 4.6 μM.
    Hydroxyakalone
  • HY-119955
    Amflutizole
    		Inhibitor
    Amflutizole (LY-141894) is an inhibitor of xanthine oxidase. Amflutizole abolishes free radical formation and release in cerebral ischemia/reperfusion mice.
    Amflutizole
  • HY-W560574
    Xanthine oxidase-IN-14
    		Inhibitor
    Xanthine oxidase-IN-14 (Compound 3f) is an inhibitor for xanthine oxidase, with IC50 >100 μM. Xanthine oxidase-IN-14 inhibits proliferations of cancer cells MCF-7, NCI-H460 and SF-268, with IC50 greater than 150 μM.
    Xanthine oxidase-IN-14
Cat. No. Product Name / Synonyms Application Reactivity